Fig. 5. Cross-species convergence in brain network adaptations to chronic stress.

Reductions of whole brain network modularity (a) global clustering coefficient (b) and increases in amygdala degree (c) and amygdala strength (d) were found in individuals with childhood trauma compared to a control group (low vs. high CTQ). Statistically different decreases are colored in dark (*p < 0.05) or light blue (^#p < 0.1), and increases in red and pink, respectively. e–h Circular network plots depicting the mouse structural covariance network at 22% density (the lowest density where between-group differences emerge) in control (e) and stress (f) conditions. g, h Human networks depicted at 12% density in (g) control (or low CTQ) and (h) stress (or high CTQ) conditions. Nodes are arranged by degree clockwise, with highest-degree node on top of the circle. Degree is further reflected in node size. The amygdala and its direct connections are highlighted in red. i, j Anatomical view of the stress effects on the amygdala structural covariance subconnectome in both human and mouse brain. Overlays represent binarized masks onto select structural MR image slices of i mouse (coronal slices: Bregma −2.10 mm (top), −3.20 mm (bottom)) and (j) human brain (MNI coordinates: x = 22, y = −2, z = −6). k–n Edge-weighted spring-embedded layout network diagram of the amygdala′s direct structural covariance connections across species (mouse—k, l; human—m, n) and conditions (control—k, m; stress l, n). In panels i–n, regions in purple are part of the amygdala’s network common to control and stress groups and in blue or red are regions unique to each group. Node size reflects overall number of connections for that node within the whole network, however only the connections with the amygdala are pictured. A full list of all visualized nodes is provided in Supplementary Tables 3, 4 and 7)