Table 1.
Response in sucrose consumption test | Experiment I | Experiment II | ||||||
---|---|---|---|---|---|---|---|---|
Controls without CMS (n = 10) Exp. #1a | CMS | CMS | ||||||
Citalopram | ECS | |||||||
Before treatment (n = 15) Exp. #1b | After treatment | Before treatment (n = 29) Exp. #2a | After treatment | |||||
Vehicle (n = 8) Exp. #1c | Citalopram (n = 7) Exp. #1d | Sham (n = 9) Exp. #2b | Cortical ECS (n = 10) Exp. #2c | Auricular ECS (n = 10) Exp. #2d | ||||
Hedonic | 8 | 2 | 1 | 0 | 6 | 3 | 6 | 2 |
Anhedonic | 0 | 10 | 7 | 7 | 17 | 6 | 2 | 8 |
Unclassifiable | 2 | 3 | 0 | 0 | 6 | 0 | 2 | 0 |
Significance of differences in proportion of hedonic rats (Fisher’s exact test) | P = 0.0024 vs. #1a | NS vs. #1b | NS vs. #1b | P = 0.0015 vs. #1a | NS vs. #2a | P = 0.0427 vs. #2a | NS vs. #2a |
As described in Methods, the animals were randomly divided into the treatment groups and it was ensured that the number of anhedonic-like, hedonic-like, and unclassifiable rats were almost the same in all treatment groups