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. 2017 Dec 18;7:1294. doi: 10.1038/s41398-017-0031-4

Fig. 1. Antidepressant effects of ketamine enantiomers in susceptible mice after CSDS.

Fig. 1

a The schedule of CSDS model, treatment, behavioral tests, and feces collection. CSDS was performed from day 1 to day 10, and social interaction test (SIT) was performed on day 11. Saline, (R)-ketamine, or (S)-ketamine were administered i.p. into CSDS-susceptible mice. Behavioral tests and SPT were performed from day 12 to day 15. On day 16, mouse feces was collected. b Body weight (time: F3,15 = 9.3, P < 0.001, treatment: F3,15 = 0.268, P = 0.848, interaction: F9,15 = 0.576, P = 0.813). c–e Behavioral tests including locomotion test (LMT; one-way ANOVA, F3,20 = 0 159, P = 0.923), TST (F3,20 = 18.362, P < 0.001) and FST (F3,20 = 15.107, P < 0.001) were performed after treatment. f SPT was performed 3 days after treatment (F3,20 = 20.287, P < 0.001). Data are shown as mean ± SEM (n = 6). *P < 0.05, **P < 0.01, ***P < 0.001. NS not significant