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. 2018 Jan 23;4:4. doi: 10.1038/s41421-017-0004-z

Fig. 7. Loss of Asxl1 dysregulates transcriptional program through RNAPII transcriptional activity.

Fig. 7

a Heatmaps of ASXL1 and RNAPII on ASXL1-bound genes in WT and Asxl1−/− BMSCs. The genes ranked from highest to lowest ASXL1 level. b Asxl1 deletion reduces genome-wide RNAPII occupancy. c RNAPII traveling ratio (TR) shows that many genes become less paused in Asxl1−/− BMSCs compared with WT controls. Lower TR values indicate a lower degree of pausing. d Average genome-wide occupancies of RNAPII in WT (blue) and Asxl1−/− (red) BMSCs on downregulated genes along the transcription unit. e RNAPII TR calculations of downregulated genes in WT and Asxl1−/− BMSCs. f, g Representative genome browser tracks showing ASXL1 and RNAPII occupancies on regions of Cxcl1, Cxcl2, and Vcam1