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. 2018 Jan 29;52:4. doi: 10.11606/S1518-8787.2018052000295

Table 2. Clinical manifestations (n = 1,251a) and hospitalization of adverse effects following immunization, number of doses per event, and rate per 10,000 doses, in children up to 24 months of age. Araraquara, state of São Paulo, Brazil, 2000 to 2013.

Clinical manifestations/Hospitalization Number of events Number of doses per event Rate per 10,000 dosesb
Local
Pain 189 4,040 2.5
Nodule 163 4,684 2.1
Abscess 33 23,138 0.4
Lymphadenitis 33 23,138 0.4
Ulcer 1 763,548 0.1
Systemic
Headache 1 763,548 0.1
Nausea 10 76,355 0.1
Diarrhea 23 33,198 0.3
Vomiting 54 14,140 0.7
Cyanosis 27 28,280 0.4
Malaise 23 33,198 0.3
Irritability 102 7,486 1.3
Sleepiness 44 17,353 0.6
Myalgia 7 109,078 0.1
Exanthema 46 16,599 0.6
Jaundice 1 763,548 0.1
Parotitis 20 38,177 0.3
Fever 344 2,220 4.5
< 38°C 51 14,971 0.7
38|-|39,4°C 196 3,896 2,6
≥ 39.5°C 68 11,229 0.9
Hypotonic-hyporesponsive episode 67 11,396 0.9
Adenoiditis 18 42,419 0.2
Arthralgia 1 763,548 0.1
Hypersensitivity 11 69,413 0.1
Seizure 25 30,542 0.3
Loss of consciousness 6 127,258 0.1
Myelitis 1 763,548 0.1
Paresis 1 763,548 0.1
Hospitalization 16 47,722 0.2
a

The 565 cases for which we had information presented 1,251 types of clinical manifestation.

b

Rate of AEFI for dose of any vaccine.