Table 3. Distribution of hypotonic-hyporesponsive events and seizures in children up to 24 months of age who received pertussis vaccine, according to sex, age, dose administered, and hospitalization. Araraquara, state of São Paulo, Brazil, 2000 to 2013.
| Variable | HHE | Seizures | |||||
|---|---|---|---|---|---|---|---|
| n (%) | Rate per 10,000 doses* | Doses per event | n (%) | Rate per 10,000 doses* | Doses per event | ||
| Sex | |||||||
| Male | 33 (49.3) | 3.9 | 2,530 | 17 (68.0) | 2.0 | 4,911 | |
| Female | 34 (50.7) | 4.1 | 2,418 | 8 (32.0) | 1.0 | 10,274 | |
| Age | |||||||
| < 12 months | 54 (80.6) | 4.3 | 2,320 | 25 (100) | 2.0 | 5,011 | |
| 12|-|24 months | 13 (19.4) | 3.2 | 3,106 | 0 (0) | - | - | |
| Median | 4 months | 4 months | |||||
| Dose administered | |||||||
| 1st dose | 29 (43.3) | 6.9 | 1,451 | 2 (8.0) | 0.5 | 21,041 | |
| 2nd dose | 16 (23.9) | 3.8 | 2,634 | 7 (28.0) | 1.7 | 6,020 | |
| 3rd dose | 13 (19.4) | 3.1 | 3,218 | 7 (28.0) | 1.7 | 5,977 | |
| 1st booster | 9 (13.4) | 2.3 | 4,400 | 9 (36.0) | 2.3 | 4,400 | |
| Hospitalization | 7 (10.5) | 0.4 | 23,667 | 8 (32.0) | 0.5 | 20,709 | |
| Total | 67 | 4.1 | 2,473 | 25 | 1.5 | 6,626 | |
HHE: hypotonic-hyporesponsive episode
*
Rate of AEFI per dose of pertussis vaccine (total number of doses = 165,669; number of males = 83,477; number of females = 82,192; number of < 12 months = 125,291; number of 12|-| 24 months = 40,378; number of 1st doses = 42,082; number of 2nd doses = 42,143; number of 3rd doses = 41,839; number of 1st boosters = 39,605).