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. 2018 Feb 6;8:2512. doi: 10.1038/s41598-018-20574-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Central metabolic pathways of methane (A) and methanol (B) utilization in Methylomicrobium alcaliphilum 20Z^R and results of FBA analyses. Red circles indicate input substrates (CH₄, O₂, or CH₃OH), White circles with red outlines indicate excreted compounds (CO₂ and acetate); thickness of arrow represents predicted value of the corresponding flux via the reaction (solid arrow) or metabolic pathway (dotted arrows); (C,D) 3D plots of comparative analysis of metabolic profiling versus predicted flux ratios between the same growth conditions (axis X – model rank; axis Y – metabolomics rank; axis Z – metabolic pathway that a compound belongs to). (C) Comparison of results for complete TCA cycle (Spearman’s index equals to 0.9, p-value = 2.7E-24); (D) Comparisons of results for branched TCA cycle and reverse phosphoketolase reaction (R = 0.99, p-value = 2E-55).