Figure 1.

Identification of three anti-cancer agents with in vivo efficacy. (a) Overall procedure of the screening process. The number in parenthesis is the total number of compounds screened. The promoter sequences, −35 and −10, in the P1 promoter are indicated. SBS, the SaeR binding site. Parts of images were adapted from Motifolio Drawing Toolkits (www.motifolio.com). (b) Chemical structures and molecular weight of the identified compounds. (c) In vivo efficacy of the identified compounds. S. aureus (2 × 10⁸ CFU) was i.p. injected into 18 mice. At 1 h post-infection, the corresponding compounds (100 μg, 5 mg/kg body weight) were i.p. injected once every day for 7 days. Statistical significance was assessed by Log-rank test. STZ, streptozotocin; FU, floxuridine.