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FoxO1 is required for the growth retardation observed in LIRKO mice. (a) Body weights and (b) body lengths of male LFKO, LIRKO, LDKO, and control mice were measured from 4 to 9 weeks of age. (c–f) Gene expression in the liver and (g) IGF1 in the plasma were measured in 8- to 10-week-old male mice using real-time PCR and an ELISA assay. Error bars represent SEM; n = 6 to 10. *P < 0.05 vs control mice; #P < 0.05 LIRKO vs LDKO; $P < 0.05 LFKO vs LDKO. N.P., not performed.
