Fig. 4.

(A) Number of studies per year (*through 4/18/14). (B) Overall adherence by study and year. Vertical lines indicate the time of publication of the *ASTM, # FDA, and § EMA documents. Regression shows slight increase in overall adherence with time (p=0.004, R²=0.07, slope=0.63%/year). C) Mean adherence per year, broken out into overall, study descriptors, and study outcomes. Study descriptors were reported at a higher level than study outcomes. Standard deviation is shown for overall adherence only. D) Adherence (in percent) across species (white bars = study descriptors, hatched bars = study outcomes, black bars = overall adherence, *P<0.05). E) Correlation between overall adherence and study duration (R²=0.075, P =0.003) and F) overall adherence and the number of animals (R²<0.001, P =0.994).