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. Author manuscript; available in PMC: 2018 Feb 7.
Published in final edited form as: Methods Enzymol. 2017 Jul 4;593:449–490. doi: 10.1016/bs.mie.2017.05.004

Fig. 7.

Fig. 7

Time sequence of 2-AG entry into the binding pocket of CB2. The rendering is described in the caption of Fig. 6. Each frame illustrates a different time point in the binding of 2-AG to CB2. (A) Sample point where 2-AG has partitioned out of bulk lipid into the TMH6/TMH7 interface. (B) Configuration at 55ns of the resampled trajectory where the 2-AG headgroup has inserted via the portal. (C) Configuration at 127ns of the resampled trajectory where the 2-AG headgroup is fully inserted.