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. 2018 Feb 7;13(2):e0192214. doi: 10.1371/journal.pone.0192214

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© 2018 Saera-Vila et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 5 — The effect of Igf signaling inhibition on EOM regeneration was analyzed using myosin expression as a marker of muscle differentiation. Uninjured EOMs of BMS754807 treated fish showed high levels of myosin staining (A, B), that were not different of those of a DMSO treated control fish. Myosin staining (yellow) of DMSO control fish at 5 dpi (E, F) and 7 dpi (M, N) reveal higher protein levels than the myosin staining of BMS754807 treated fish at 5 dpi (I, J) and 7 dpi (Q, R). The dashed box shows the approximate position of the magnification shown in B, F, J, N and R. DAPI staining of the corresponding myosin staining picture (C, G, K, O and S) and DIC images (D, H, L, P and T) are also shown. DAPI staining shows hypercellularity in BMS754807 (K, S compared to C, G, O) and typical elongated muscle nuclei in DMSO 7 dpi (O) and Uninjured EOMs (C). Pictures are representative examples of 7 fish per group, time and treatment.