Table 1. The incident cases and age-adjusted incidence rate of head and neck squamous cell carcinoma per 100,000 inhabitants by site and gender during the period between 1988 and 2012 in Italy.
| Site of HNSCC | Total | Males | Females | M/F ratio | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| n | % | IR | n | % | IR | n | % | IR | ||
| HPV-related | 3984 | 14.1 | 1.8 | 3250 | 13.8 | 3.1 | 734 | 15.3 | 0.6 | 4.4 |
| base of tongue | 934 | 3.3 | 0.4 | 769 | 3.3 | 0.7 | 165 | 3.4 | 0.1 | 4.7 |
| tonsil | 2079 | 7.3 | 0.9 | 1655 | 7.0 | 1.6 | 424 | 8.8 | 0.4 | 3.9 |
| other oropharyngeal sites | 971 | 3.4 | 0.4 | 826 | 3.5 | 0.8 | 145 | 3.0 | 0.1 | 5.7 |
| HPV-unrelated | ||||||||||
| Oral cavity | 7816 | 27.6 | 3.3 | 5277 | 22.5 | 5.0 | 2539 | 53 | 1.8 | 2.1 |
| Larynx/Hypopharynx | 16495 | 58.3 | 6.9 | 14975 | 63.7 | 13.8 | 1520 | 31.7 | 1.2 | 9.9 |
| All sites | 28295 | 100 | 13.8 | 23502 | 100 | 25.3 | 4793 | 100 | 4.2 | 4.9 |
HNSCC, head and neck squamous cell carcinoma; IR, incident rate; HPV, human papillomavirus