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Changes in plasma creatinine levels after adenine administration and during the observation period in (A) mice and (B) rats. Levels of plasma BUN in (C) mice and (D) rats at day 70 and 66, respectively. * P < 0.05, ** P < 0.01, *** P < 0.001 vs. vehicle-treated mice or rats (corresponding time points) respectively; † P < 0.05, †† P < 0.01 vs. vehicle-treated mice at 28 days.
