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Changes in plasma erythropoietin (EPO) levels after adenine administration and during the observation period in (A) mice and (B) rats. Levels of plasma ferritin in (c) rats at day 66. * P < 0.05, ** P < 0.01, *** P < 0.001 vs. vehicle-treated mice or rats (corresponding time points) respectively; †† P < 0.01, ††† P < 0.001 vs. vehicle-treated mice at 28 days.
