Table 1. Plasma biochemical, hematological, metabolic and urinary parameters in rodents with adenine-induced renal injury.
| Parameters | Mice | Rats | ||||||
|---|---|---|---|---|---|---|---|---|
| Day | Vehicle | 25 mg/kg | 50 mg/kg | Day | Vehicle | 200 mg/kg | 600 mg/kg | |
| Plasma Creatinine (mg/dL) | 28 | 0.3 ± 0.01 | 0.8 ± 0.1 | 1.8 ± 0.1*** | 10 | 0.5 ± 0.04 | 1.1 ± 0.1 | 3.02 ± 0.02*** |
| 70 | 0.2 ± 0.03 | - | 1.2± 0.1** | 84 | 0.7 ± 0.02 | 1.0 ± 0.06 | 2.3 ± 0.3*** | |
| Plasma BUN (mg/dL) | 70 | 36.6 ± 1.1 | - | 73 ± 3.7*** | 66 | 24 ± 0.9 | 56 ± 2.2* | 142 ± 1.9*** |
| Hematocrit (%) | 28 | 49.6 ± 1.6 | 48.6 ± 0.9 | 36.5 ± 1.0*** | 10 | 43.5 ± 2.2 | 41.7 ± 1.0 | 40.1 ± 1.2 |
| 70 | 49.5 ± 0.7 | - | 33.9 ± 1.1*** | 84 | 43.4 ± 1.5 | 44.1 ± 1.7 | 30.1 ± 1.0*** | |
| Hemoglobin (g/dl) | 70 | 16.8 ± 0.2 | - | 12.9 ± 0.2*** | 66 | 17.0 ± 0.1 | 14.2 ± 0.5 | 11.9 ± 0.5*** |
| Total RBC (x104/ μL) | - | - | - | - | 763 | 763 ± 4.9 | 642 ± 20.3 | - |
| Plasma EPO (pg/mL) | 28 | 60.9 ± 4.0 | 44.8 ± 2.5 | 27.8 ± 2.3*** | 10 | 28.4 ± 3.7 | 7.5 ± 1.6*** | 2.0 ± 0.8*** |
| 70 | - | - | 16.6 ± 4.7††† | 84 | 28.6 ± 2.6 | 23.2 ± 3.4 | 13.1 ± 2.5** | |
| Plasma ferritin (ng/mL) | - | - | - | - | 66 | 238 ± 36 | 388± 29* | 404 ± 42* |
| Plasma γ-GT (U/L) | - | - | - | - | 66 | 3.4 ± 0.2 | 3.8 ± 0.1 | 4.3 ± 0.2 |
| Food intake (mL) | 4.8 ± 0.3 | - | 4.9 ± 0.2 | 66 | 13.0 ± 0.7 | 15.9 ± 0.6 | 14.3 ± 1.1 | |
| Water intake (mL) | 5.9 ± 0.2 | - | 13 ± 0.4*** | 66 | 19.0 ± 1.1 | 38.8 ± 2.0 | 62.7 ± 4.1*** | |
| Urine volume (mL) | 70 | 2.0 ± 0.2 | - | 7.9 ± 0.5*** | 66 | 11.7 ± 0.8 | 26 ± 2.1* | 47 ± 3.5*** |
| Urine protein (mg/day) | 70 | 5.6 ± 0.5 | - | 9.7 ± 1.4* | 66 | 5.7 ± 0.6 | 6.7 ± 1.0 | 24 ± 6.0*** |
Data are mean ± SE.
* P < 0.01
** P < 0.01
*** P < 0.001 vs. vehicle-treated mice or rats (corresponding time points) respectively
††† P < 0.001 vs. vehicle-treated mice at 28 days.