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Confirmation of bioactivity against the IRE1α/XBP1 pathway, a branch of the UPR. The HT1080 (human fibrosarcoma) cell line was stably transduced with an XBP1-luciferase reporter construct. (top) Generated SMILES expressions, (middle) structures, and (bottom) dose–response curves showing inhibitory action relative to CMV control toward IRE1α/XBP1 are presented for the two identified inhibitors, (A) STF-021898 and (B) STF-046304.
