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. Author manuscript; available in PMC: 2018 Feb 7.
Published in final edited form as: J Chem Inf Model. 2017 Apr 3;57(4):875–882. doi: 10.1021/acs.jcim.6b00754

Table 1.

Structures and Properties of the Novel VEGFR-2 Inhibitors Synthesized

Cpd. ID Structure Name MW (Da) Purity (%)
1 SN38501 graphic file with name nihms936971t1.jpg (S)-1-(3-((3-((4-chloro-3-(propylcarbamoyl)phenyl)carbamoyl)-4-methylphenyl)carbamoyl)benzyl)pyrrolidine-2-carboxamide 576.09 97.3
2 SN38502 graphic file with name nihms936971t2.jpg 1-(2-((4-(3-amino-1H-indazol-4-yl)phenyl)amino)pyrimidin-5-yl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea 522.47 95.2
3 SN38488 graphic file with name nihms936971t3.jpg N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-(2-methyl-6-((pyridin-4-ylmethyl)amino)phenyl)-1,3,4-oxadiazol-2-amine 415.45 97.7
4 SN38676 graphic file with name nihms936971t4.jpg N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-(2-(((2-methyl-1H-indol-5-yl)methyl)amino)phenyl)-1,3,4-oxadiazol-2-amine 453.5 99.4
5 SN38677 graphic file with name nihms936971t5.jpg N-(3,4-dichlorophenyl)-4-(quinolin-6-ylmethyl)phthalazin-1-amine 431.32 96.1
Ref. Vatalanib graphic file with name nihms936971t6.jpg N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine 346.81 N/A