Table 5. Cardiovascular screening history before starting pharmacotherapy.

Screening parameters	Screening history
Symptoms*	Unusual fatigue associated with physical activity (more than or different from others)
	Pain, discomfort, or pressure in chest during exercise
	Pre-syncope or syncope during or after exercise, emotion, or startle
	Dizziness associated with exercise
	Shortness of breath associated with exercise (more than or different from others)
	Heart racing or skipped beats
Medical history and review of systems	Unexplained seizures*
	Detailed history of any congenital structural heart disease*
	Use of cardiac pacemaker or implanted cardiac defibrillator*
	History of Kawasaki disease*
	History of rheumatic fever*—known heart murmur
	Systemic hypertension
	Substance abuse, tobacco use
	Use of excessive caffeine or energy drinks
	Any previous recommendations to restrict physical activity
Family history*	Sudden or unexpected death of family members before age 50 years
	Coronary artery disease before age 50 years
	Family members using pacemaker or implanted cardiac defibrillator
	Family history of cardiomyopathies, long QT syndrome, short QT syndrome, or Brugada syndrome
	Family history of primary pulmonary hypertension

*, positive screening should warrant further cardiac evaluation.