Table 7. Non-stimulant medications (10-15).

Drug brand	Formulation (mg)	Dosing	Duration (hrs)	Comments
Strattera (atomoxetine:norepinephrine reuptake inhibitor)	Capsule: 10, 18, 25, 40, 60	Initial: <70 kg, 0.5 mg/kg; >70 kg, 40 mg daily. Titration: <70 kg, increase after 1 week to 1.2 mg/kg as single or divided dose; >70 kg, increase to 80 mg over 1 week as single or divided dose. Max: 1.4 mg/kg/day up to 100 mg/day	10–12	Dose adjustment required in hepatic impairment. Takes several weeks to see effect. May be stopped without taper. Single daily dose recommended
Kapvay* (clonidine extended release; alpha-2-agonist)	Tablet: 0.1, 0.2	Initial: 0.1 mg/day at bedtime. Titration: 0.1 mg/week and divided BID. Max: 0.4 mg/day divided BID	12–24	If stopping therapy taper daily dose by ≤0.1 mg every 3 to 7 days
Intuniv* (guanfacine extended release; alpha-2-agonist)	Tablet: 1, 2, 3, 4	Initial: 0.05–0.08 mg/kg/dose or 1 mg daily. Titration: no more than 1 mg/week. Max: 6–12 yr: 4 mg/day	12–24	Taper the dose in decrement of ≤1 mg every 3 to 7 days

Drug brand names refer to United States brand names. *, approved for use in patients with ADHD ages 6 years and older. hrs, hours; max, maximum; mg, milligrams; yr, years old; BID, twice daily; ER, extended release; kg, kilograms; max, maximum; mg, milligrams.