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. 2018 Feb 7;8:2551. doi: 10.1038/s41598-018-20793-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The lipidomic architecture of the constituent layers of the SVZ. (a) Histology-guided delineation of the four SVZ layers as analysis regions in SCiLS Lab software, with example m/z signals shown that were found to co-localise with the ependymal layer, hypocellular layer or the myelin layer. Scale bar: 50 µm. (b,c) Volcano plots of individual m/z signals in positive and negative polarity with log2 transformed fold differences plotted against P-values arising from one-sample t-tests. Summary spectra for each layer (including the astrocytic ribbon) were obtained and log2 fold-differences and t-test P-values derived by comparing, for each m/z signal, its intensity value in the summary spectrum for each layer with the mean intensity of the summary spectra corresponding to the three other SVZ layers. L1 = ependymal layer; L3 = hypocellular layer; L4 = myelin layer. Lipid species that are discussed in the text are arbitrarily marked in red here and the assignments for these are indicated.