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. 2018 Feb 7;8:2586. doi: 10.1038/s41598-018-21049-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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In DNFB-induced dermatitis, degrees of inflammation and dermatitis scores in NC.h2^b/nc and NC.h2^b/b are alleviated compared with NC/Nga. A. Gross lesion of DNFB-induced dermatitis shown for each H-2 congenic mice on day 14. B. MPO activity by in vivo Imaging System shown for each H-2 congenic mice on day 14. C. The gross lesion at day 14 of DNFB-induced dermatitis in each H-2 congenic mice was evaluated by a scoring index of atopic dermatitis. *NC/Nga vs. NC.h2^b/b or NC.h2^b/nc, p < 0.05 ANOVA. D. The scoring index of DNFB-induced dermatitis in NC/Nga, NC.h2^b/b and NC.h2^b/nc are indicated. E. The concentration of serum IL-18, IL-33 and IgE in each mouse on day 14 were measured by ELISA method. *DNFB vs. control, p < 0.05, ANOVA. ^†NC.h2^b/b vs. NC/Nga, p < 0.05, ANOVA.