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. 2018 Feb 7;8:2586. doi: 10.1038/s41598-018-21049-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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In axillary lymph nodes (LNs) with DNFB-induced dermatitis, the production of IFN-γ and IL-17 from autoreactive CD4⁺ T-cells in NC.h2^b/b is increased compared with that in NC/Nga. The autoreactive proliferation of CD4⁺ T-cells purified from axillary LNs was analyzed by co-culturing with naïve CD11b⁺ myeloid cells from the same strain. Growth picture (A) and graph of MTT assay (B) are indicated. *DNFB vs. control, p < 0.05, ANOVA. ^†NC.h2^b/b vs. NC/Nga, p < 0.05, ANOVA. (C) The levels of IL-17, IFN-γ and IL-4 in culture supernatant was analyzed by the ELISA method. P/I; PMA⁺ Ionomycin. *DNFB vs. control, p < 0.05, ANOVA. ^†P/I vs. Nil, p < 0.05, ANOVA. The bar graphs (n = 4) are indicated as mean ± SD.