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. 2018 Feb 7;8:2575. doi: 10.1038/s41598-018-19426-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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An example of the reconstructions from different quality of the projections of the mouse brain sample. The top row is a slice that reconstructed from the CNN enhanced projections. The four small images in the middle rows are different reconstructions for the section of the blue-dash rectangular window above. They are the reconstructions from the projections with 2 s exposure, the projections enhanced with CNN, the projections denoised with median filter and TV respectively. The plots in the bottom row are the profiles taken from the dash lines of the four small images.