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. 2018 Feb 7;8:2579. doi: 10.1038/s41598-018-20950-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Improved neurological morphology and function of sciatic nerve in DPN rats after the intrathecal injection of IRE1α siRNA. (A) Transfection of IRE1α siRNA increased the myelin sheath area and myelinated nerve fibers in DPN rats. Representative pictures of Luxol fast blue (LFB) staining (magnification 40×) of myelin sheath and ultrastructure (magnification 6000×) of myelinated nerve fibers. (B) Myelin sheath area expressed as mean ± SEM of the percentage of the respective controls and analyzed using one-way ANOVA with LSD analysis or unpaired Student’s t-test. (C) The number of myelinated nerve fibers expressed as mean ± SEM of the percentage of the respective controls and analyzed using one-way ANOVA with LSD analysis or unpaired Student’s t-test. (D) Representative Western blots using tissue extracts from the sciatic nerve and probed with antibodies against PGP9.5. β-actin was probed as loading control. (E) The intensity of PGP9.5 expressed as mean ± SEM of the percentage of the respective controls and analyzed using one-way ANOVA with LSD analysis or unpaired Student’s t-test. (F) NCV reported as mean ± SEM and analyzed using one-way ANOVA with LSD analysis or unpaired Student’s t-test. ^ΔΔP < 0.01, compared to control; ^##P < 0.01, compared to DPN; **P < 0.01 (N = 6 per group).