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. 2018 Feb 7;8:2545. doi: 10.1038/s41598-018-20244-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Transcriptomic changes in the mBMSCs caused by DEX-plus-GA treatment. (A) Heat map of differential gene expression in mBMSCs treated with GA (50 μM) plus DEX vs. DMSO plus DEX for 3 d (n = 2). (B) The most up-regulated and down-regulated pathways in the GA-plus-DEX treatment group revealed by DAVID GO analyses. Genes that showed significant difference between GA and DMSO treatments (p < 0.05) and had a log₂ fold change > 0.5 or < –0.5 were chosen for analysis. (C) GSEA analyses of up-regulated and down-regulated gene sets (NES: normalized enrichment score; p: nominal p-value; q: false discovery rate q-value). (D) Altered expression of adipogenic genes in the mBMSCs treated with GA (50 μM) plus DEX vs. DMSO plus DEX for 4 d (**p < 0.01; n = 4).