Fig. 3.

Fused lasso preserves cell-type specificity of Hi-C contact matrices (high sequencing depth = 80 million intrachromosomal read pairs). a Effect of fused lasso on stratum-adjusted correlation coefficient for the case of intra-cell-type (cyan) and inter-cell-type (orange) comparisons. Matrices of 40 kb resolution were used for the analysis. The Hi-C matrices were processed with ICE, calCB, or scaling matrix correction methods. b Difference in mean stratum-adjusted correlation coefficient between intra-cell-type and inter-cell-type sample comparisons. c Comparison of Hi-C matrix “correction” and smoothing methods in terms of preservation of cell-type specificity (x-axis) and intra-cell-type reproducibility (y-axis). d Comparison of Hi-C matrix “correction” and smoothing methods in terms of (1—inter-cell-type) (x-axis) and intra-cell-type (y-axis) stratum-adjusted correlation coefficients