Table 1.

The clinicopathological trait associations of HuMi_Aged

Trait	Estimate	Std. error	t-value	p-value
Age at death	0.0046	0.0014	3.2633	0.0012
Sex	−0.0399	0.0194	−2.0560	0.0403
Clinical AD	0.0282	0.0193	1.4623	0.1443
Global AD pathology	0.0174	0.0267	0.6500	0.5160
Amyloid load	0.0219	0.0086	2.5575	0.0108
Tau tangle density	0.0021	0.0075	0.2732	0.7848
APOE haplotype	0.0061	0.0023	2.6285	0.0088
APOEe4 count	0.0306	0.0199	1.5412	0.1239
APOEe2 count	−0.0625	0.0228	−2.7387	0.0064

A meta-feature constructed from the HuMi_Aged gene set revealed its association with age at death and APOE ε2 in the bulk tissue RNA-Seq dataset (N = 540). Please note, the reference sex was male—women have a greater HuMi_Aged signature, on average. Five hypotheses were tested in primary analysis, accordingly the significance threshold was p < 0.01