Fig. 3.

Dose-dependent LLLA analgesic effects and a comparison with EA-induced analgesia. Comparison of the effects on PI-induced nociceptive hypersensitivity between irradiation durations and between LLLA and EA. Two RED-LA durations, 15 min (RED-15) and 30 min (RED-30), were employed. a, b Mechanical allodynia. c, d Heat hyperalgesia. e, f Mechanical and heat hypersensitivity in the ipsilateral hind paw. *p < 0.05, **p < 0.01 for groups vs. PI group, #p < 0.05, ##p < 0.01 for groups vs. RED-30 group through one-way ANOVA with Tukey’s post hoc test. N = 5 (control), N = 6 (PI), N = 7 (RED-15), N = 6 (RED-30), and N = 6 (EA)