Table 3.

Markers of DDS/ICD symptoms or dyskinesias in logistic regression (n=654)

		Univariable		Multivariable
Outcome	Independent Variable	Odds Ratio (95% CI)	p	Odds Ratio (95% CI)	p
DDS/ICD symptom presence	Psychotic symptom presence	5.34 (2.71–10.22)	<0.001***	4.30 (2.07–8.62)	<0.001***
	Depression (clinically significant)	3.36 (1.64–6.54)	<0.001***	2.37 (1.09–4.86)	0.023*
	Complexity of fluctuations score	1.55 (1.19–1.97)	<0.001***	1.36 (1.02–1.79)	0.026*
	DA-LEDD (mg/day)/100	1.10 (1.01–1.28)	0.067	1.07 (0.98–1.22)	0.180
	Age at diagnosis	0.97 (0.94–0.996)	0.024*	0.97 (0.94–1.00)	0.0504
Dyskinesia presence	Disease duration (years)	1.18 (1.13–1.22)	<0.001***	1.25 (1.17–1.33)	<0.001***
	Mean akinesia-rigidity score	1.22 (0.88–1.67)	0.222	2.43 (1.42–4.17)	0.002**
	Interaction: Disease duration and mean akinesia-rigidity score	—		0.92 (0.87–0.96)	<0.001***
	Psychotic symptom presence	2.81 (1.62–4.83)	<0.001***	2.43 (1.27–4.57)	0.006**
	Mean tremor items score	0.47 (0.27–0.80)	0.007**	0.49 (0.28–0.83)	0.0096**
	LEDD (mg/day)/100	1.10 (1.06–1.14)	<0.001***	1.05 (1.01–1.09)	0.013*
	Male sex	0.74 (0.51–1.07)	0.107	0.62 (0.40–0.94)	0.025*
	Depression (clinically significant)	2.81 (1.65–4.76)	<0.001***	1.75 (0.94–3.20)	0.074
	DA-LEDD (mg/day)/100	1.01 (0.92–1.09)	0.816	0.91 (0.80–1.01)	0.166

Independent variables for regression were identified through backward stepwise regression. Two separate models were produced, one with DDS/ICD symptom presence as the outcome, the other with dyskinesia presence as the outcome. Clinically significant depression was considered present if a score of ≥ 10 was reached on the HAM-D-17.

^*p<0.05;

^**p<0.01;

^***p<0.001