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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: Bioorg Med Chem. 2017 Dec 17;26(3):573–580. doi: 10.1016/j.bmc.2017.12.018

Fig. 7.

Fig. 7

A. A simplified ergosterol biosynthetic pathway and products resulting from inhibition of ERG11. B–E. GC-MS chromatograms of the sterols extracted from untreated and antifungal-treated C. albicans ATCC 10231 (strain A). The fungal strain treated with DMSO (no drug control, panel B), VOR at 0.12 μg/mL (panel C), compound 8 at 0.48 μg/mL (panel D), and compound 9 at 0.975 μg/mL (panel E). The peaks in these chromatograms are for lanosterol (1), ergosterol (2), eburicol (3), 14α-methyl ergosta-8,24(28)-dien-3β,6α-diol (4). F. A table summarizing the percentage of each sterol from panels B–E.