Table 2.

MIC values^a (in μg/mL) (the corresponding values in μM are provided in Table S2) determined for compounds 5–16 and for two control antifungal agents (FLC and VOR) against various non-albicans Candida and Cryptococcus neoformans clinical isolates. Each experiment was performed in triplicate.

	Yeast strains
Cpd #	H	CG1	CG2	CG3	J	CP1	CP2	CP3	CN1	CN2	CN3
5	7.8	31.3	7.8	31.3	0.975	0.975	0.975	0.975	7.8	>31.3	31.3
6	0.975	7.8	0.975	15.6	0.06	0.48	0.12	0.24	1.95	3.9	3.9
7	0.48	1.95	0.48	3.9	0.03	0.06	0.12	0.24	0.24	0.24	0.48
8	0.975	1.95	0.975	1.95	0.48	0.06	0.24	0.12	0.24	0.24	0.48
9	1.95	1.95	1.95	3.9	0.48	0.48	0.975	0.48	0.12	0.24	0.48
10	>31.3	1.95	0.975	7.8	0.48	0.975	0.48	0.975	0.48	0.48	0.48
11	>31.3	>31.3	>31.3	>31.3	>31.3	31.3	31.3	31.3	>31.3	>31.3	>31.3
12	3.9	15.6	1.95	31.3	0.24	0.12	0.12	0.12	0.48	1.95	1.95
13	>31.3	>31.3	>31.3	>31.3	31.3	>31.3	>31.3	>31.3	>31.3	>31.3	15.6
14	31.3	15.6	7.8	31.3	0.975	0.975	1.95	1.95	>31.3	>31.3	>31.3
15	31.3	31.3	15.6	31.3	3.9	0.975	0.975	1.95	7.8	>31.3	15.6
16	>31.3	7.8	7.8	7.8	7.8	3.9	3.9	3.9	7.8	31.3	>31.3
CAS	0.06	1.95	0.24	0.975	1.95	0.48	0.48	0.48	15.6	31.3	15.6
FLC	62.5	>31.3	>31.3	>31.3	1.95	0.975	0.975	0.975	7.8	>31.3	>31.3
VOR	0.24	0.975	3.9	>31.3	<0.03	<0.03	<0.03	<0.03	0.24	0.975	0.12

Yeast strains: H = Candida glabrata ATCC 2001, CG1–CG3 = C. glabrata clinical isolates, J = Candida parapsilosis ATCC 22019, CP1–CP3 = C. parapsilosis clinical isolates, CN1–CN3 = Cryptococcus neoformans clinical isolates.

Known antifungal agents: CAS = caspofungin, FLC = fluconazole, VOR = voriconazole.

^aFor these yeast strains: MIC-0 values are reported for FLC analogues 5-16, whereas MIC-2 values are reported for azoles.