Table 3.
MIC valuesa (in μg/mL) determined for compounds 7–9 and for two control antifungal agents (AmB and VOR) against various yeast strains and filamentous fungi in the absence or presence of FBS. Each experiment was performed in triplicate.
| Yeast strains | Filamentous fungi | |||||
|---|---|---|---|---|---|---|
| Cpd # | Candida albicans ATCC 10231 (A) (no FBS) | Candida albicans ATCC 10231 (A) (+10% FBS) | Candida parapsilosis ATCC 22019 (J) (no FBS) | Candida parapsilosis ATCC 22019 (J) (+10% FBS) | Aspergillus nidulans ATCC 38163 (L) (no FBS) | Aspergillus nidulans ATCC 38163 (L) (+10% FBS) |
| 7 | 0.48 | 0.48 | 0.03 | 0.06 | 0.975 | 1.95 |
| 8 | 0.975 | 1.95 | 0.48 | 0.24 | 1.95 | 7.8 |
| 9 | 1.95 | 7.8 | 0.48 | 0.975 | 3.9 | 31.2 |
| AmB | 3.9 | 7.8 | 1.95 | 15.6 | 3.9 | 15.6 |
| VOR | 0.48 | 0.48 | 0.015 | 0.015 | 0.12 | 0.12 |