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Published in final edited form as: Alzheimers Dement. 2017 Sep 12;14(2):167–177. doi: 10.1016/j.jalz.2017.07.757

Comparison of the magnitude of adjusted associations across estimates of the added impact of midlife lipids, midlife hypertension, and APOE E4 status on 20-year cognitive decline in (a) DSST z-scores and (b) summary z-scores

Abbreviations: DSST, Digit-Symbol Substitution Test; LDL-c, low density lipoprotein cholesterol; HDL-c, high density lipoprotein cholesterol

*From Gottesman et al. (2014) JAMA Neurology

†From a model adjusting for total cholesterol and all other covariates included in the primary analyses

‡Conversions to SI units - Total cholesterol: 200mg/dL = 5.17 mmol/L, 240 mg/dL = 6.21 mmol/L; LDL-c: 100 mg/dL = 2.59 mmol/L, 130 mg/dL = 3.36 mmol/L, 160 mg/dL = 4.14 mmol/L, 190 mg/dL = 4.91 mmol/L; HDL-c: 40 mg/dL = 1.03 mmol/L, 60 mg/dL = 1.55 mmol/L; Triglycerides: 150 mg/dL = 1.69 mmol/L, 200 mg/dL = 2.26 mmol/L, 500 mg/dL = 5.65 mmol/L

Comparison of the magnitude of adjusted associations across estimates of the added impact of midlife lipids, midlife hypertension, and APOE E4 status on 20-year cognitive decline in (a) DSST z-scores and (b) summary z-scores

Abbreviations: DSST, Digit-Symbol Substitution Test; LDL-c, low density lipoprotein cholesterol; HDL-c, high density lipoprotein cholesterol

*From Gottesman et al. (2014) JAMA Neurology

†From a model adjusting for total cholesterol and all other covariates included in the primary analyses

‡Conversions to SI units - Total cholesterol: 200mg/dL = 5.17 mmol/L, 240 mg/dL = 6.21 mmol/L; LDL-c: 100 mg/dL = 2.59 mmol/L, 130 mg/dL = 3.36 mmol/L, 160 mg/dL = 4.14 mmol/L, 190 mg/dL = 4.91 mmol/L; HDL-c: 40 mg/dL = 1.03 mmol/L, 60 mg/dL = 1.55 mmol/L; Triglycerides: 150 mg/dL = 1.69 mmol/L, 200 mg/dL = 2.26 mmol/L, 500 mg/dL = 5.65 mmol/L