Table 2.

Average adjusted difference in 20-year decline in cognitive test z-scores per 10 mg/dL^‡ higher plasma lipid levels at Visit 2 in participants of the Atherosclerosis Risk in Communities Study (1990–2013)

	Difference in 20-year cognitive change*
	Summary Z-score		DWRT Z-score		DSST Z-score		WFT Z-score
	Estimate (95%CI)	P-value	Estimate (95%CI)	P-value	Estimate (95%CI)	P-value	Estimate (95%CI)	P-value
Total Cholesterol (n=12,232)	−0.007 (−0.012, −0.002)	0.004	−0.01 (−0.017, −0.002)	0.02	−0.006 (−0.009, −0.003)	0.0006	−0.004 (−0.009, 0.000)	0.06
LDL-c (n=12,017)	−0.004 (−0.009, 0.001)	0.16	−0.006 (−0.015, 0.002)	0.14	−0.004 (−0.008, −0.001)	0.02	−0.003 (−0.007, 0.002)	0.24
HDL-c (n=12,195)	−0.003 (−0.016, 0.009)	0.59	−0.005 (−0.026, 0.015)	0.61	0.007 (−0.002, 0.016)	0.15	−0.003 (−0.014, 0.009)	0.64
Triglycerides† (n=12,151)	−0.006 (−0.009, −0.003)	<0.0001	−0.006 (−0.011, −0.002)	0.007	−0.005 (−0.007, −0.003)	<0.0001	−0.003 (−0.005, −0.000)	0.03

Abbreviations: CI, Confidence interval; DSST, Digit-Symbol Substitution Test; DWRT, Delayed Word Recall Test; LDL-c, low density lipoprotein cholesterol; HDL-c, high density lipoprotein cholesterol; WFT, word fluency test

^*Adjusted for baseline age, age squared, education, sex, race-center, APOE ε4 status, body mass index, alcohol use, smoking status, diabetes, hypertension, physical activity, health insurance status, adherence to a western dietary pattern, adherence to a prudent dietary pattern, and lipid-lowering medication use, including both their main effects and their interactions with time on study.

^†Within the range of 0 to 500mg/dL (0 to 5.65 mmol/L)

^‡In mmol/L:Total cholesterol, LDL-c, HDL-c: per 0.26 mmol/L, Triglycerides: per 0.11 mmol/L higher.