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. Author manuscript; available in PMC: 2019 Mar 15.
Published in final edited form as: Toxicol Lett. 2018 Jan 4;285:113–120. doi: 10.1016/j.toxlet.2017.12.027

Figure 1.

Figure 1

TCE and Benfluorex are inhibitory of HNF4a-mediated transcription. A luciferase reporter assay was performed with HepG2 cells and an HNF4a regulated reporter plasmid with varied doses of Benfluorex or TCE. HepG2 cells were chosen for their endogenous expression of HNF4a (Liu et al., 2014). Both TCE and Benfluorex were significant inhibitors of luciferase expression in vitro at the doses tested. Values are the average of 4-10 independent measurements for each exposure. Error bars indicate S.E.M. All treatments are significant, P<.001.