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. Author manuscript; available in PMC: 2019 Mar 15.
Published in final edited form as: Toxicol Lett. 2018 Jan 4;285:113–120. doi: 10.1016/j.toxlet.2017.12.027

Figure 4.

Figure 4

TCE effects switch from inhibition to induction of selected markers in chick hearts. The two highest linked genes in the TCE interactome, HNF4a and TRAF6, were measured in the heart after in ovo injection of varied doses. Comparison was made with CYP2C45 as a potential target of HNF4a. TCE exposure significantly reduced mRNA expression of these markers at 10 ppb. Exposure at 1 ppm TCE significantly increases expression of HNF4a and TRAF6. Expression of CYP2C45 is increased at exposure levels of 100 ppb and 1 ppm. Significance calculated by Student's T-test for values obtained (unpaired, two-tailed).*p< 0.05, **p<0.005.