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. Author manuscript; available in PMC: 2019 Mar 15.
Published in final edited form as: Toxicol Lett. 2018 Jan 4;285:113–120. doi: 10.1016/j.toxlet.2017.12.027

Figure 5.

Figure 5

Benfluorex inhibits marker expression in chick hearts. Benfluorex was injected M at the same concentrations used for TCE and the markers shown in Fig. 4 were compared. Benfluorex exposure in the heart significantly reduced mRNA expression of CYP2C45 at the lowest dose (1ppb) and the highest doses (100 ppb and 1 ppm). TRAF6 showed significantly increased expression at 1ppb and decreased expression at all other doses but 1 ppm. Benfluorex showed no significant effect on the regulation of HNF4a expression at any dose tested although it was inhibitory at the higher doses tested in cell culture in Figure 1. The data show that TCE and Benfluorex are not acting identically on the HNF4a transcription complex. Significance calculated by Student's T-test for values obtained (unpaired, two-tailed).*p< 0.05, **p<0.005.