Table 1.

Differentially expressed miRNAs and their molecular target(s) in OA

miRNA	Differential expression in OA	Target gene(s)	Biological effects	References
miR-22	Upregulated	PPARα, BMP7, ACAN	Lipid metabolism	[29]
miR-9	Upregulated	MMP-13, MCPIP1	Matrix degradation	[30] [31]
miR-25	Upregulated	COX-2	Inflammation	[30] [32]
miR-602	Upregulated	SHH	Chondrocytes homeostasis	[33]
miR-608	Upregulated	SHH	Chondrocytes homeostasis	[33]
miR-139	Upregulated	MCPIP1	Inflammation	[31]
miR-27a	Downregulated	MMP-13, IGFBP5	Matrix degradation	[34]
miR-27b	Downregulated	MMP-13	Matrix degradation	[35]
miR-140	Downregulated	ADAMTS-5, MMP-13	Matrix degradation	[36]
miR199a	Downregulated	COX-2	Inflammation	[35]
miR-138	Downregulated	Sp1, HIF2α	Chondrocytes differentiation	[37] [38]