Table 2.
Differentially expressed lncRNAs and their role in OA pathogenesis
| Target lncRNA | Expression in OA | Molecular effects in OA | References |
|---|---|---|---|
| HOTAIR | Upregulation | ECM degradation, Apoptosis, | [49] [50] |
| GAS5 | Upregulation | ECM degradation, Apoptosis | [49] |
| PCGEM1 | Upregulation | Apoptosis | [51] |
| HOTTIP | Upregulation | ECM degradation | [52] |
| LncRNA-CIR | Upregulation | ECM degradation | [48] |
| H19 | Downregulation | ECM degradation | [49] |
| MEG3 | Downregulation | Angiogenesis | [53] |
| CILinc01 | Downregulation | Inflammation | [54] |
| CILinc02 | Downregulation | Inflammation | [54] |