Table 4.

Further Examples of Amide Dehydration^a

^aReaction conditions: amide (0.5 or 1.0 mmol), copper(II) acetate (0.02 equiv), 1,2-bis(dicyclohexylphosphino)ethane (0.022 equiv), dimethoxy(methyl)silane (3 equiv) in THF (1 mL) at RT for 12 h, unless otherwise specified; see supporting information for details. Yield represents average isolated yield of two or more replicates.

^b5 equiv silane was used.

^cAt 40 °C instead of RT; 1,4-dioxane (2 mL) was used instead of THF.

^dYield as measured by gas chromatography, relative to an internal standard.