Receiver operating characteristics—Area under the curve for the different cohorts analyzed. The lines correspond for the accuracy of obtained for the models that included gender, study, age (for late-onset data sets), and APOE ε4/ε2 alleles. Abbreviations: fEOAD, familial early-onset Alzheimer’s disease; fLOAD, familial late-onset Alzheimer’s disease; sEOAD, sporadic early-onset Alzheimer’s disease; sLOAD, sporadic late-onset Alzheimer’s disease.