Skip to main content
. Author manuscript; available in PMC: 2019 Feb 6.
Published in final edited form as: Structure. 2018 Jan 11;26(2):187–198.e4. doi: 10.1016/j.str.2017.12.010

Figure 7. FXIaiPD blocks inhibition of intrinsic pathway-triggered thrombin generation by DEF in human plasma.

Figure 7

(A) FXIIa-induced thrombin activity in human plasma as a function of time was determined in the presence of DEF at 16 μg/ml and the indicated concentration of FXIaiPD. A representative set of curves is shown.

(B, C) Quantitation of thrombin peak activity (B) and lag time (C) plotted as a function of FXIaiPD concentration. Data shown are mean +/− SEM (n=3).