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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Curr Cancer Drug Targets. 2018;18(9):905–911. doi: 10.2174/1568009617666170808105633

Figure 4. Inhibition of AR prevents the expression of inflammatory and pre-neoplastic markers in the large intestines of HFD-treated ApcMin/+ mice.

Figure 4

Histological sections of small intestines from HFD- and HFD+Fidarestat- treated mice were stained with antibodies against COX-2 (a), iNOS (b), phospho-AKT (c), PKCβ2 (d), PCNA (e), phospho- NF-κB (f) and β-catenin (g). Immunoreactivity of the antibody was assessed by dark brown staining in the intestinal cells, whereas the non-reactive areas displayed only the background color. Photomicrographs of the stained sections were acquired using an EPI-800 microscope (bright-field) connected to a Nikon camera (X400 magnification). A representative image from each group is shown. Con, control; HFD, high fat diet; HFD + Fid, high fat diet + fidarestat.