Figure 4.

NOS inhibition with 4 mg/kg LNAME caused a significant transient increase in myocardial T1 in WT mice but not in eNOS^−/− mice. An example anatomical image used to visualize myocardial borders is shown in (A). R1 maps of the heart of eNOS^−/− mice acquired before and 5 minutes after injection of 4 mg/kg LNAME are shown in (B) and (C), respectively. The time course of the change in myocardial T1 after intravenous injection of LNAME is shown in (D) for WT and eNOS^−/− mice.