Table 1.
Cytotoxicity of PTL and selected parthenologs against various cell lines. LC50 values are mean ± SD (n = 6).
| Compound | Jurkat (blood) | Jeko-1 (blood) | HeLa (cervix) | A549 (lung) | HCT-116 (colon) | SJSA-1 (bone) | SK-N-MC (brain) | PC-3 (prostate) | MDA-MB-231 (breast) | SK-MEL-2 (skin) |
|---|---|---|---|---|---|---|---|---|---|---|
| PTL | 16.9 ± 3.0 | 10.0 ± 1.1 | 9.0 ± 0.8 | 29.7 ± 1.7 | 18.0 ± 1.7 | 42.4 ± 3.9 | 4.7 ± 0.8 | 20.5 ± 1.3 | 18.3 ± 1.1 | 24.9 ± 3.8 |
| 6 (9–32) | - | - | - | - | 11.8 ± 2.7 | - | - | - | - | - |
| 7 (14–32) | - | 6.7 ± 0.5 | - | - | - | - | - | - | - | - |
| 8 (9–33) | 2.8 ± 0.2 | 3.5 ± 0.3 | - | - | 7.9 ± 0.3 | - | - | - | 7.2 ± 0.7 | - |
| 9 (14–33) | 3.3 ± 0.2 | 3.4 ± 0.4 | 1.5 ± 0.1 | 5.5 ± 0.4 | 5.9 ± 0.2 | 9.2 ± 0.0 | 0.6 ± 0.2 | 5.5 ± 0.2 | 6.1 ± 0.6 | 4.3 ± 0.9 |
| 13 (14–35) | - | - | 1.7 ± 0.1 | - | 7.8 ± 0.4 | - | - | 5.7 ± 0.2 | - | - |
| 16 (9–12) | - | - | 2.1 ± 0.1 | - | - | - | 5.7 ± 0.2 | 5.3 ± 0.2 | 5.7 ± 0.9 | - |
| 17 (14–12) | - | - | 2.9 ± 0.1 | - | 8.2 ± 0.6 | 7.7 ± 0.6 | 5.6 ± 0.2 | 6.7 ± 0.5 | - | - |
| 18 (9–13) | 1.2 ± 0.1 | 1.2 ± 0.1 | - | - | - | - | 4.7 ± 0.5 | 3.1 ± 0.2 | 3.8 ± 0.4 | 2.6 ± 0.2 |
| 19 (14–13) | 1.9 ± 0.1 | 1.7 ± 0.2 | 1.5 ± 0.1 | 4.9 ± 0.2 | 5.7 ± 0.2 | 6.4 ± 0.8 | 0.6 ± 0.2 | 4.7 ± 0.4 | 6.2 ± 0.7 | - |
| 24 (14–18) | - | - | - | - | 11.8 ± 1.6 | - | - | - | - | - |
| 25 (9–19) | - | - | - | - | 8.3 ± 0.3 | - | - | - | - | - |
| 27 (14–20) | 2.3 ± 0.3 | - | 1.7 ± 0.1 | - | 7.1 ± 0.3 | 6.7 ± 0.5 | - | - | - | - |