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. 2018 Feb 8;38(1):BSR20171323. doi: 10.1042/BSR20171323

Figure 6. The effect of n-alcohols and isoflurane on GJ conductance of Cx31-EGFP.

Figure 6

(A) Typical effects of octanol and heptanol on Cx31-EGFP GJ conductance in HeLa cells. (B) Summary of the effects of n-alcohols and isoflurane on GJ conductance of Cx31-EGFP in HeLa cells. The effect of pentanol (5 mM), hexanol (5 mM), heptanol (3 mM), octanol (3 mM), and isoflurane (3 mM) was 0.95 ± 0.50 (n=5), 0.90 ± 0.03 (n=8), 0.96 ± 0.02 (n=4), 0.03 ± 0.01 (n=6), and 0.75 ± 0.10 (n=4), respectively. (C) Comparison of the effects of pentanol (5 mM), hexanol (5 mM), heptanol (3 mM), and nonanol (0.5 mM) on gj of Cx36-EGFP and Cx36C87S-EGFP GJ channels. The effect was 2.4 ± 0.2 (n=7) and 1.1 ± 0.1 (n=9); 3.4 ± 0.3 (n=9), and 1.4 ± 0.3 (n=10); 3.0 ± 0.4 (n=7) and 0.6 ± 0.1 (n=8); 0.1 ± 0.1 (n=10), and 0.1 ± 0.1 (n=5), respectively. **P<0.005; ***P<0.001.