Table 3.

Echocardiographic data on heart geometry and function at baseline (0) age 12 and endpoint (16) age 28 weeks (mean ± SEM)

Parameter		NS (n = 3)	HS (n = 5)	OVX NS (n = 3)	OVX HS (n = 4)	Effect of diet a and/or OVX b and/or time t
IVSd (mm)	0	1.0 ± 0.07	1.1 ± 0.09	1.3 ± 0.11	0.9 ± 0.13
	16	1.2 ± 0.04	1.8 ± 0.03d	1.4 ± 0.19	1.7 ± 0.08	a, c
IVSs (mm)	0	1.6 ± 0.07	1.8 ± 0.25	2.1 ± 0.46	1.5 ± 0.21
	16	2.1 ± 0.02	2.7 ± 0.13	2.3 ± 0.28	2.6 ± 0.01	c
PWd (mm)	0	1.0 ± 0.06	1.1 ± 0.10	1.2 ± 0.18	0.9 ± 0.02
	16	1.2 ± 0.11	2.0 ± 1.28d	1.4 ± 0.11	1.8 ± 0.10d	a, c
PWs (mm)	0	1.5 ± 0.02	1.6 ± 0.17	1.8 ± 0.16	1.5 ± 0.08
	16	1.7 ± 0.13	2.5 ± 0.06d	2.0 ± 0.18	2.5 ± 0.10d	a, c
LVIDd (mm)	0	6.7 ± 0.08	6.9 ± 0.22	7.6 ± 0.76	7.5 ± 0.24
	16	7.4 ± 0.28	6.8 ± 0.27	8.3 ± 0.14	7.6 ± 0.14	a,b
LVIDs (mm)	0	4.2 ± 0.02	4.5 ± 0.29	4.3 ± 0.02	5.2 ± 0.25
	16	4.7 ± 0.21	4.3 ± 0.07	5.6 ± 0.17	4.3 ± 0.15	a,b
RWT	0	0.30 ± 0.02	0.29 ± 0.02	0.31 ± 0.03	0.24 ± 0.02
	16	0.33 ± 0.02	0.57 ± 0.04d	0.29 ± 0.00	0.46 ± 0.03	a, c
LVMi (g/cm)	0	0.123 ± 0.006	0.119 ± 0.008	0.129 ± 0.007	0.114 ± 0.008
	16	0.164 ± 0.002	0.255 ± 0.012d	0.185 ± 0.011	0.253 ± 0.012d	a, c
HR (bpm)	0	338 ± 11	327 ± 14	379 ± 5	363 ± 11	b
	16	350 ± 16	363 ± 13	374 ± 37	368 ± 7
SV (μL)	0	151 ± 5	156 ± 17	161 ± 11	172 ± 12
	16	191 ± 14	157 ± 21	223 ± 8	222 ± 11	b
CO (mL/min)	0	51 ± 27	47 ± 47	61 ± 49	62 ± 38
	16	67 ± 38	55 ± 10	86 ± 83	82 ± 55	b
EF (%)	0	66 ± 0.6	63 ± 5	71 ± 6	57 ± 3
	16	66 ± 0.7	65 ± 3	69 ± 2	73 ± 2d	a
FS (%)	0	37 ± 0.5	35 ± 4	42 ± 5	31 ± 2
	16	37 ± 0.4	37 ± 2	33 ± 1	44 ± 2d	a
MFS (%)	0	20 ± 0.7	18 ± 1	20 ± 2	19 ± 0.8
	16	20 ± 0.6	14 ± 2d	19 ± 0.9	18 ± 1	a
E to E′ ratio	16	15.7 ± 1.6	15.6 ± 0.6	10.0 ± 1.9	13.7 ± 1.3	b

i index tibia length.

^a P < 0.05 for the effect of diet.

^b P < 0.05 for the effect of OVX.

^c P < 0.05 for the effect of time.

^d P < 0.05 versus, corresponding NS.