Table 3.
Clinical Performance of the tHDA Assay Compared with Microscopy/NASBAMT
| Microscopy/NASBAMA |
||||
|---|---|---|---|---|
| Positive | Negative | Total | ||
| P.falciparum | ||||
| HDA | Positive | 38 | 0 | 38 |
| Negative | 1 | 49 | 50 | |
| Total | 39 | 49 | 88 | |
| 95% CI | ||||
| Sensitivity (%) | 97.4 | 84.9–99.9 | ||
| Specificity (%) | 100.0 | 90.9–100.0 | ||
| P.vivax | ||||
|---|---|---|---|---|
| HDA | Positive | 16 | 0 | 16 |
| Negative | 0 | 72 | 72 | |
| Total | 16 | 71 | 88 | |
| 95% CI | ||||
| Sensitivity (%) | 100.0 | 75.9–100.0 | ||
| Specificity (%) | 100.0 | 93.7–100.0 | ||
| Other Plasmodium | ||||
|---|---|---|---|---|
| HDA | Positive | 3 | 0 | 3 |
| Negative | 1 | 84 | 85 | |
| Total | 4 | 84 | 88 | |
| 95% CI | ||||
| Sensitivity (%) | 75.0 | 21.9–98.7 | ||
| Specificity (%) | 100.0 | 94.6–100.0 | ||
| Overall | ||||
|---|---|---|---|---|
| HDA | Positive | 57 | 0 | 57 |
| Negative | 2 | 29 | 31 | |
| Total | 59 | 29 | 88 | |
| 95% CI | ||||
| Sensitivity (%) | 96.6 | 87.3–99.4 | ||
| Specificity (%) | 100.0 | 85.4–100.0 | ||