Figure 1.

Simvastatin lowered plasma lipid and attenuated increases in exercise capacity in response to exercise in ApoE^−/− mice. ApoE^−/− mice were assigned to three groups: sedentary, exercise, and exercise + simvastatin (SMV). (A) Plasma glucose and lipid concentrations were measured before sacrifice. (B) Plasma creatine kinase (CK) concentrations were measured before sacrifice. (C) Exercise capacity tests were performed at the end of experiment. An inverted grip‐hanging test was performed and time to fall off was recorded. Forelimb grip strength was measured by using a grip strength metre. Running distance and running time were measured by a treadmill. N = 6. ^* P < 0.05 and ^*** P < 0.001 vs. sedentary; ^# P < 0.05, ^## P < 0.01 and ^### P < 0.001 vs. exercise. Glu, glucose; TC, total cholesterol; HDL‐C, high‐density lipoprotein cholesterol; LDL‐C, low‐density lipoprotein cholesterol; NEFA, non‐esterified fatty acid; TG, triglyceride.